| Product revenues, net | 409.69M |
| Royalty revenues | 3.84M |
| Collaborative revenues | 259K |
| Total revenues | 413.78M |
| Cost of product revenues | 53.22M |
| Royalty expenses | 855K |
| Research and development expenses | 272.37M |
| Sales, general and administrative expenses | 106.06M |
| Restructuring expense | 8K |
| Total costs and expenses | 432.51M |
| Loss from operations | -18.73M |
| Interest income | |
| Interest expense | |
| Change in fair value of derivative instruments | |
| Loss before provision for income taxes | -39.03M |
| Provision for income taxes (Alios) | 503K |
| Net loss | -39.54M |
| Net loss attributable to noncontrolling interest (Alios) | 696K |
| Net loss attributable to Vertex | -38.84M |
| Basic net loss attributable to Vertex per common share (in dollars per share) | -0.16 |
| Diluted net loss attributable to Vertex per common share (in dollars per share) | -0.16 |
| Basic weighted-average number of common shares outstanding (in shares) | 244.92M |
| Diluted weighted-average number of common shares outstanding (in shares) | 244.92M |