| Net loss | -91.19M |
| Depreciation and amortization | |
| Non-cash stock compensation | 7.81M |
| Non-cash interest expense | 166K |
| Amounts due from collaboration partner, prepaid expenses and other assets | -2.83M |
| Accounts payable | 666K |
| Accrued expenses | 1.6M |
| Deferred rent | 1K |
| Deferred revenue | -898K |
| Net cash used in operating activities | -84.06M |
| Purchase of equipment | |
| Net cash used in investing activities | -868K |
| Proceeds from exercise of stock options | 10.15M |
| Principal payments on long-term debt | -9.19M |
| Proceeds from issuance of common stock, net of issuance costs of $6,211 and $7,111 during 2011 and 2010, respectively | 123.35M |
| Net cash provided by financing activities | 124.31M |
| Net increase in cash and cash equivalents | 39.37M |
| Cash and cash equivalents - Beginning of period | 127.08M |
| Cash and cash equivalents - End of period | 166.46M |
| Interest | 892K |
| Value of warrants exercised by converting warrants into shares of common stock ("net issuance method") | |
| Disposal of equipment (fully depreciated) | 117K |