| Net loss | -86.84M |
| Realized gains on sales of current marketable securities | |
| Depreciation and amortization | |
| Stock-based compensation | 21.85M |
| Amortization of convertible senior notes discount and debt issuance costs | 6.3M |
| Changes in fair value of liability for contingent consideration | |
| Property and equipment write-off | |
| Impairment of equity investment | |
| Restricted cash | |
| Receivable from collaboration partners | -52.19M |
| Prepaid expenses and other current assets | 10.63M |
| Other assets | -817K |
| Accounts payable | 2.56M |
| Accrued liabilities | -3.93M |
| Accrued clinical trials and related expenses | -1.83M |
| Accrued compensation | -7.08M |
| Escrow liability | |
| Lease termination exit costs liability | |
| Other liabilities | 961K |
| Net cash used in operating activities | |
| Purchases of marketable securities | -276.27M |
| Sales of marketable securities | 16.18M |
| Maturities of marketable securities | 165.96M |
| Transfers from restricted cash | |
| Payment for liability for contingent consideration, current | |
| Capital expenditures | |
| Net cash provided by investing activities | |
| Repurchases of restricted stock awards | |
| Net proceeds from issuances of common stock | 389.6M |
| Net cash provided by financing activities | |
| Net increase (decrease) in cash and cash equivalents | |
| Cash and cash equivalents at beginning of period | 153.24M |
| Cash and cash equivalents at end of period | 323.07M |
| Cash paid during the period for income taxes | 34K |
| Cash paid during the period for interest | 4.6M |