| Net loss | -399.11M |
| Depreciation and amortization | 5.12M |
| Accretion of discount on securities | |
| Stock-based compensation | 28.91M |
| Receivable from collaboration partners | |
| Prepaid expenses and other current assets | -19.96M |
| Other non-current assets | |
| Accounts payable | |
| Accrued expenses | |
| Other current liabilities | |
| Deferred revenue | |
| Other non-current liabilities | |
| Net cash used in operating activities | |
| Purchase of short-term investments | |
| Maturities of short-term investments | |
| Purchase of property and equipment | -13.93M |
| Net cash provided by investing activities | |
| Stock option exercises | |
| Net proceeds from stockholder securities law settlement | |
| Net cash provided by financing activities | |
| Net increase (decrease) in cash and cash equivalents | 41.91M |
| Cash and cash equivalents at beginning of period | 225.85M |
| Cash and cash equivalents at end of period | 267.76M |