| Net income (loss) | -551.5M |
| Depreciation and amortization | |
| Amortization of discount on investments | 681K |
| Equity in the loss of BioMarin/Genzyme LLC | |
| Stock-based compensation | 97.22M |
| Net gain from sale of investments | |
| Deferred income taxes | -206.69M |
| Excess tax benefit from stock option exercises | -563K |
| Unrealized foreign exchange (gain) loss on forward contracts | -10.96M |
| Changes in the fair value of contingent acquisition consideration payable | |
| Accounts receivable, net | -52.02M |
| Inventory | -59.8M |
| Other current assets | |
| Other assets | -5M |
| Accounts payable and accrued liabilities | -77.85M |
| Other long-term liabilities | -4.45M |
| Net cash provided by operating activities | |
| Purchases of property, plant and equipment | -96.81M |
| Maturities and sales of investments | 302.8M |
| Purchase of available-for-sale investments | |
| Business acquisitions, net of cash acquired | -1.47M |
| Investments in BioMarin/Genzyme LLC | |
| Net cash provided by (used in) investing activities | |
| Proceeds from Employee Stock Purchase Plan (ESPP) and exercise of stock options | 49.5M |
| Excess tax benefit from stock option exercises | 563K |
| Payment of contingent acquisition consideration payable | |
| Repayment of capital lease obligations | |
| Net cash provided by financing activities | |
| NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS | 310.31M |
| Beginning of period | 397.04M |
| End of period | 707.35M |
| Cash paid for interest, net of interest capitalized into fixed assets | 4.56M |
| Cash paid for income taxes | 95.16M |
| Stock-based compensation capitalized into inventory | 8.96M |
| Depreciation capitalized into inventory | |
| Changes in accrued liabilities related to fixed assets | |
| Equipment acquired through capital leases | |