| Net loss | -193.1M |
| Depreciation and amortization | 8.61M |
| Deferred income taxes | |
| Non-cash income tax benefit | |
| Non-cash stock-based compensation | 39.3M |
| Charge for 401(k) company stock match | |
| Equity in loss of joint venture (Regulus Therapeutics Inc.) | |
| Collaboration receivables | -1.22M |
| Income taxes receivable | |
| Prepaid expenses and other assets | -5.59M |
| Accounts payable | -3.59M |
| Income taxes payable | |
| Accrued expenses and other | 1.72M |
| Deferred revenue | 5.38M |
| Net cash used in operating activities | |
| Purchases of property and equipment | -24.38M |
| Purchases of marketable securities | |
| Sales and maturities of marketable securities | 605.98M |
| Net cash provided by (used in) investing activities | |
| Proceeds from issuance of common stock | 6.27M |
| Proceeds from issuance of shares to Novartis | 0 |
| Net cash provided by financing activities | |
| Effect of exchange rate on cash | |
| Net decrease in cash and cash equivalents | 90.18M |
| Cash and cash equivalents, beginning of period | 180.9M |
| Cash and cash equivalents, end of period | 271.08M |