Kura Oncology reports darlifarnib plus cabozantinib shows activity in kidney cancer
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Kura Oncology Reports Darlifarnib Plus Cabozantinib Demonstrates Robust Activity in Patients With Clear Cell Renal Cell Carcinoma Previously Treated With Cabozantinib
April 17, 2026 6:00 AM EDTData from subset analysis of cabozantinib-pretreated patients support potential to overcome resistance and resensitize tumors to VEGF TKI therapy
44% ORR and 94% DCR in ccRCC patients previously treated with cabozantinib, with tumor shrinkage observed in 75% of patients
Responses observed in heavily pretreated patients, including those with stable disease on prior cabozantinib
Durable treatment durations reaching 56 weeks, with one-third of patients remaining on therapy at time of data cut-off
Manageable safety and tolerability profile in all RCC patients across multiple... More
