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   <title>Form  4          AGENUS INC                For: Jun 12  Filed by: ARMEN GARO H</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++4++++++++++AGENUS+INC++++++++++++++++For%3A+Jun+12++Filed+by%3A+ARMEN+GARO+H/26651378.html</link>
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   <pubDate>Tue, 16 Jun 2026 09:00:00 -0400</pubDate>
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   <title>Form  4          AGENUS INC                For: Jun 12  Filed by: ARMEN GARO H</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++4++++++++++AGENUS+INC++++++++++++++++For%3A+Jun+12++Filed+by%3A+ARMEN+GARO+H/26651378.html</link>
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   <pubDate>Tue, 16 Jun 2026 09:00:00 -0400</pubDate>
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   <title>Agenus Announces Virtual 2026 Annual Shareholders Meeting</title>
   <link>http://www.streetinsider.com/Press+Releases/Agenus+Announces+Virtual+2026+Annual+Shareholders+Meeting/26592179.html</link>
   <description>
&lt;p&gt;    LEXINGTON, Mass.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=http%3A%2F%2Fwww.agenusbio.com&amp;amp;esheet=54546598&amp;amp;newsitemid=20260602350009&amp;amp;lan=en-US&amp;amp;anchor=Agenus+Inc.&amp;amp;index=1&amp;amp;md5=b10c6e9a1c76104083a74ce12453b782&quot; shape=&quot;rect&quot;&gt;Agenus Inc.&lt;/a&gt; (“Agenus”) (NASDAQ: AGEN), a leader in immuno-oncology innovation, today announced that its Annual Shareholders Meeting will begin at 10:00 a.m. ET on June 16, 2026, and will be conducted in a virtual format only. Registration for attendees will start at 9:45 a.m. ET.

&lt;/p&gt;&lt;p&gt;
To participate in the Annual Shareholders Meeting, shareholders should visit &lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=http%3A%2F%2Fwww.virtualshareholdermeeting.com%2FAGEN2026&amp;amp;esheet=54546598&amp;amp;newsitemid=20260602350009&amp;amp;lan=en-US&amp;amp;anchor=www.virtualshareholdermeeting.com%2FAGEN2026&amp;amp;index=2&amp;amp;md5=e061d12f8d05f0b3534174d87aae1e16&quot; shape=&quot;rect&quot;&gt;www.virtualshareholdermeeting.com/AGEN2026&lt;/a&gt; and enter the 16-digit control number found in their proxy materials. Guests may also access the Annual Shareholders Meeting, but in listen-only mode. No control number is required for guests.

&lt;/p&gt;&lt;p&gt;
&lt;b&gt;Webcast Information:&lt;/b&gt;

&lt;/p&gt;&lt;p&gt;
&lt;b&gt;Date&lt;/b&gt;:</description>
   <guid isPermaLink="true">http://www.streetinsider.com/Press+Releases/Agenus+Announces+Virtual+2026+Annual+Shareholders+Meeting/26592179.html</guid>
   <pubDate>Tue, 02 Jun 2026 16:30:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">A.50213496</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">AGEN</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.00638659</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.02746585</category>
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  <item>
   <title>Agenus Announces Virtual 2026 Annual Shareholders Meeting</title>
   <link>http://www.streetinsider.com/Press+Releases/Agenus+Announces+Virtual+2026+Annual+Shareholders+Meeting/26592179.html</link>
   <description>
&lt;p&gt;    LEXINGTON, Mass.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=http%3A%2F%2Fwww.agenusbio.com&amp;amp;esheet=54546598&amp;amp;newsitemid=20260602350009&amp;amp;lan=en-US&amp;amp;anchor=Agenus+Inc.&amp;amp;index=1&amp;amp;md5=b10c6e9a1c76104083a74ce12453b782&quot; shape=&quot;rect&quot;&gt;Agenus Inc.&lt;/a&gt; (“Agenus”) (NASDAQ: AGEN), a leader in immuno-oncology innovation, today announced that its Annual Shareholders Meeting will begin at 10:00 a.m. ET on June 16, 2026, and will be conducted in a virtual format only. Registration for attendees will start at 9:45 a.m. ET.

&lt;/p&gt;&lt;p&gt;
To participate in the Annual Shareholders Meeting, shareholders should visit &lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=http%3A%2F%2Fwww.virtualshareholdermeeting.com%2FAGEN2026&amp;amp;esheet=54546598&amp;amp;newsitemid=20260602350009&amp;amp;lan=en-US&amp;amp;anchor=www.virtualshareholdermeeting.com%2FAGEN2026&amp;amp;index=2&amp;amp;md5=e061d12f8d05f0b3534174d87aae1e16&quot; shape=&quot;rect&quot;&gt;www.virtualshareholdermeeting.com/AGEN2026&lt;/a&gt; and enter the 16-digit control number found in their proxy materials. Guests may also access the Annual Shareholders Meeting, but in listen-only mode. No control number is required for guests.

&lt;/p&gt;&lt;p&gt;
&lt;b&gt;Webcast Information:&lt;/b&gt;

&lt;/p&gt;&lt;p&gt;
&lt;b&gt;Date&lt;/b&gt;:</description>
   <guid isPermaLink="true">http://www.streetinsider.com/Press+Releases/Agenus+Announces+Virtual+2026+Annual+Shareholders+Meeting/26592179.html</guid>
   <pubDate>Tue, 02 Jun 2026 16:30:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">A.50213496</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">AGEN</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.00638659</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.02746585</category>
   	  </item>
  <item>
   <title>Agenus Announces Virtual 2026 Annual Shareholders Meeting</title>
   <link>http://www.streetinsider.com/Press+Releases/Agenus+Announces+Virtual+2026+Annual+Shareholders+Meeting/26592179.html</link>
   <description>
&lt;p&gt;    LEXINGTON, Mass.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=http%3A%2F%2Fwww.agenusbio.com&amp;amp;esheet=54546598&amp;amp;newsitemid=20260602350009&amp;amp;lan=en-US&amp;amp;anchor=Agenus+Inc.&amp;amp;index=1&amp;amp;md5=b10c6e9a1c76104083a74ce12453b782&quot; shape=&quot;rect&quot;&gt;Agenus Inc.&lt;/a&gt; (“Agenus”) (NASDAQ: AGEN), a leader in immuno-oncology innovation, today announced that its Annual Shareholders Meeting will begin at 10:00 a.m. ET on June 16, 2026, and will be conducted in a virtual format only. Registration for attendees will start at 9:45 a.m. ET.

&lt;/p&gt;&lt;p&gt;
To participate in the Annual Shareholders Meeting, shareholders should visit &lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=http%3A%2F%2Fwww.virtualshareholdermeeting.com%2FAGEN2026&amp;amp;esheet=54546598&amp;amp;newsitemid=20260602350009&amp;amp;lan=en-US&amp;amp;anchor=www.virtualshareholdermeeting.com%2FAGEN2026&amp;amp;index=2&amp;amp;md5=e061d12f8d05f0b3534174d87aae1e16&quot; shape=&quot;rect&quot;&gt;www.virtualshareholdermeeting.com/AGEN2026&lt;/a&gt; and enter the 16-digit control number found in their proxy materials. Guests may also access the Annual Shareholders Meeting, but in listen-only mode. No control number is required for guests.

&lt;/p&gt;&lt;p&gt;
&lt;b&gt;Webcast Information:&lt;/b&gt;

&lt;/p&gt;&lt;p&gt;
&lt;b&gt;Date&lt;/b&gt;:</description>
   <guid isPermaLink="true">http://www.streetinsider.com/Press+Releases/Agenus+Announces+Virtual+2026+Annual+Shareholders+Meeting/26592179.html</guid>
   <pubDate>Tue, 02 Jun 2026 16:30:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">A.50213496</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">AGEN</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.00638659</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.02746585</category>
   	  </item>
  <item>
   <title>Agenus Announces Virtual 2026 Annual Shareholders Meeting</title>
   <link>http://www.streetinsider.com/Press+Releases/Agenus+Announces+Virtual+2026+Annual+Shareholders+Meeting/26592179.html</link>
   <description>
&lt;p&gt;    LEXINGTON, Mass.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=http%3A%2F%2Fwww.agenusbio.com&amp;amp;esheet=54546598&amp;amp;newsitemid=20260602350009&amp;amp;lan=en-US&amp;amp;anchor=Agenus+Inc.&amp;amp;index=1&amp;amp;md5=b10c6e9a1c76104083a74ce12453b782&quot; shape=&quot;rect&quot;&gt;Agenus Inc.&lt;/a&gt; (“Agenus”) (NASDAQ: AGEN), a leader in immuno-oncology innovation, today announced that its Annual Shareholders Meeting will begin at 10:00 a.m. ET on June 16, 2026, and will be conducted in a virtual format only. Registration for attendees will start at 9:45 a.m. ET.

&lt;/p&gt;&lt;p&gt;
To participate in the Annual Shareholders Meeting, shareholders should visit &lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=http%3A%2F%2Fwww.virtualshareholdermeeting.com%2FAGEN2026&amp;amp;esheet=54546598&amp;amp;newsitemid=20260602350009&amp;amp;lan=en-US&amp;amp;anchor=www.virtualshareholdermeeting.com%2FAGEN2026&amp;amp;index=2&amp;amp;md5=e061d12f8d05f0b3534174d87aae1e16&quot; shape=&quot;rect&quot;&gt;www.virtualshareholdermeeting.com/AGEN2026&lt;/a&gt; and enter the 16-digit control number found in their proxy materials. Guests may also access the Annual Shareholders Meeting, but in listen-only mode. No control number is required for guests.

&lt;/p&gt;&lt;p&gt;
&lt;b&gt;Webcast Information:&lt;/b&gt;

&lt;/p&gt;&lt;p&gt;
&lt;b&gt;Date&lt;/b&gt;:</description>
   <guid isPermaLink="true">http://www.streetinsider.com/Press+Releases/Agenus+Announces+Virtual+2026+Annual+Shareholders+Meeting/26592179.html</guid>
   <pubDate>Tue, 02 Jun 2026 16:30:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">A.50213496</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">AGEN</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.00638659</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.02746585</category>
   	  </item>
  <item>
   <title>Agenus Announces Virtual 2026 Annual Shareholders Meeting</title>
   <link>http://www.streetinsider.com/Business+Wire/Agenus+Announces+Virtual+2026+Annual+Shareholders+Meeting/26592179.html</link>
   <description>
&lt;p&gt;    LEXINGTON, Mass.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=http%3A%2F%2Fwww.agenusbio.com&amp;amp;esheet=54546598&amp;amp;newsitemid=20260602350009&amp;amp;lan=en-US&amp;amp;anchor=Agenus+Inc.&amp;amp;index=1&amp;amp;md5=b10c6e9a1c76104083a74ce12453b782&quot; shape=&quot;rect&quot;&gt;Agenus Inc.&lt;/a&gt; (“Agenus”) (NASDAQ: AGEN), a leader in immuno-oncology innovation, today announced that its Annual Shareholders Meeting will begin at 10:00 a.m. ET on June 16, 2026, and will be conducted in a virtual format only. Registration for attendees will start at 9:45 a.m. ET.

&lt;/p&gt;&lt;p&gt;
To participate in the Annual Shareholders Meeting, shareholders should visit &lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=http%3A%2F%2Fwww.virtualshareholdermeeting.com%2FAGEN2026&amp;amp;esheet=54546598&amp;amp;newsitemid=20260602350009&amp;amp;lan=en-US&amp;amp;anchor=www.virtualshareholdermeeting.com%2FAGEN2026&amp;amp;index=2&amp;amp;md5=e061d12f8d05f0b3534174d87aae1e16&quot; shape=&quot;rect&quot;&gt;www.virtualshareholdermeeting.com/AGEN2026&lt;/a&gt; and enter the 16-digit control number found in their proxy materials. Guests may also access the Annual Shareholders Meeting, but in listen-only mode. No control number is required for guests.

&lt;/p&gt;&lt;p&gt;
&lt;b&gt;Webcast Information:&lt;/b&gt;

&lt;/p&gt;&lt;p&gt;
&lt;b&gt;Date&lt;/b&gt;:</description>
   <guid isPermaLink="true">http://www.streetinsider.com/Business+Wire/Agenus+Announces+Virtual+2026+Annual+Shareholders+Meeting/26592179.html</guid>
   <pubDate>Tue, 02 Jun 2026 16:30:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">A.50213496</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">AGEN</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.00638659</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.02746585</category>
   	  </item>
  <item>
   <title>Agenus Announces Virtual 2026 Annual Shareholders Meeting</title>
   <link>http://www.streetinsider.com/Business+Wire/Agenus+Announces+Virtual+2026+Annual+Shareholders+Meeting/26592179.html</link>
   <description>
&lt;p&gt;    LEXINGTON, Mass.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=http%3A%2F%2Fwww.agenusbio.com&amp;amp;esheet=54546598&amp;amp;newsitemid=20260602350009&amp;amp;lan=en-US&amp;amp;anchor=Agenus+Inc.&amp;amp;index=1&amp;amp;md5=b10c6e9a1c76104083a74ce12453b782&quot; shape=&quot;rect&quot;&gt;Agenus Inc.&lt;/a&gt; (“Agenus”) (NASDAQ: AGEN), a leader in immuno-oncology innovation, today announced that its Annual Shareholders Meeting will begin at 10:00 a.m. ET on June 16, 2026, and will be conducted in a virtual format only. Registration for attendees will start at 9:45 a.m. ET.

&lt;/p&gt;&lt;p&gt;
To participate in the Annual Shareholders Meeting, shareholders should visit &lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=http%3A%2F%2Fwww.virtualshareholdermeeting.com%2FAGEN2026&amp;amp;esheet=54546598&amp;amp;newsitemid=20260602350009&amp;amp;lan=en-US&amp;amp;anchor=www.virtualshareholdermeeting.com%2FAGEN2026&amp;amp;index=2&amp;amp;md5=e061d12f8d05f0b3534174d87aae1e16&quot; shape=&quot;rect&quot;&gt;www.virtualshareholdermeeting.com/AGEN2026&lt;/a&gt; and enter the 16-digit control number found in their proxy materials. Guests may also access the Annual Shareholders Meeting, but in listen-only mode. No control number is required for guests.

&lt;/p&gt;&lt;p&gt;
&lt;b&gt;Webcast Information:&lt;/b&gt;

&lt;/p&gt;&lt;p&gt;
&lt;b&gt;Date&lt;/b&gt;:</description>
   <guid isPermaLink="true">http://www.streetinsider.com/Business+Wire/Agenus+Announces+Virtual+2026+Annual+Shareholders+Meeting/26592179.html</guid>
   <pubDate>Tue, 02 Jun 2026 16:30:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">A.50213496</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">AGEN</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.00638659</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.02746585</category>
   	  </item>
  <item>
   <title>Agenus Announces Virtual 2026 Annual Shareholders Meeting</title>
   <link>http://www.streetinsider.com/Business+Wire/Agenus+Announces+Virtual+2026+Annual+Shareholders+Meeting/26592179.html</link>
   <description>
&lt;p&gt;    LEXINGTON, Mass.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=http%3A%2F%2Fwww.agenusbio.com&amp;amp;esheet=54546598&amp;amp;newsitemid=20260602350009&amp;amp;lan=en-US&amp;amp;anchor=Agenus+Inc.&amp;amp;index=1&amp;amp;md5=b10c6e9a1c76104083a74ce12453b782&quot; shape=&quot;rect&quot;&gt;Agenus Inc.&lt;/a&gt; (“Agenus”) (NASDAQ: AGEN), a leader in immuno-oncology innovation, today announced that its Annual Shareholders Meeting will begin at 10:00 a.m. ET on June 16, 2026, and will be conducted in a virtual format only. Registration for attendees will start at 9:45 a.m. ET.

&lt;/p&gt;&lt;p&gt;
To participate in the Annual Shareholders Meeting, shareholders should visit &lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=http%3A%2F%2Fwww.virtualshareholdermeeting.com%2FAGEN2026&amp;amp;esheet=54546598&amp;amp;newsitemid=20260602350009&amp;amp;lan=en-US&amp;amp;anchor=www.virtualshareholdermeeting.com%2FAGEN2026&amp;amp;index=2&amp;amp;md5=e061d12f8d05f0b3534174d87aae1e16&quot; shape=&quot;rect&quot;&gt;www.virtualshareholdermeeting.com/AGEN2026&lt;/a&gt; and enter the 16-digit control number found in their proxy materials. Guests may also access the Annual Shareholders Meeting, but in listen-only mode. No control number is required for guests.

&lt;/p&gt;&lt;p&gt;
&lt;b&gt;Webcast Information:&lt;/b&gt;

&lt;/p&gt;&lt;p&gt;
&lt;b&gt;Date&lt;/b&gt;:</description>
   <guid isPermaLink="true">http://www.streetinsider.com/Business+Wire/Agenus+Announces+Virtual+2026+Annual+Shareholders+Meeting/26592179.html</guid>
   <pubDate>Tue, 02 Jun 2026 16:30:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">A.50213496</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">AGEN</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.00638659</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.02746585</category>
   	  </item>
  <item>
   <title>Agenus Announces Virtual 2026 Annual Shareholders Meeting</title>
   <link>http://www.streetinsider.com/Business+Wire/Agenus+Announces+Virtual+2026+Annual+Shareholders+Meeting/26592179.html</link>
   <description>
&lt;p&gt;    LEXINGTON, Mass.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=http%3A%2F%2Fwww.agenusbio.com&amp;amp;esheet=54546598&amp;amp;newsitemid=20260602350009&amp;amp;lan=en-US&amp;amp;anchor=Agenus+Inc.&amp;amp;index=1&amp;amp;md5=b10c6e9a1c76104083a74ce12453b782&quot; shape=&quot;rect&quot;&gt;Agenus Inc.&lt;/a&gt; (“Agenus”) (NASDAQ: AGEN), a leader in immuno-oncology innovation, today announced that its Annual Shareholders Meeting will begin at 10:00 a.m. ET on June 16, 2026, and will be conducted in a virtual format only. Registration for attendees will start at 9:45 a.m. ET.

&lt;/p&gt;&lt;p&gt;
To participate in the Annual Shareholders Meeting, shareholders should visit &lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=http%3A%2F%2Fwww.virtualshareholdermeeting.com%2FAGEN2026&amp;amp;esheet=54546598&amp;amp;newsitemid=20260602350009&amp;amp;lan=en-US&amp;amp;anchor=www.virtualshareholdermeeting.com%2FAGEN2026&amp;amp;index=2&amp;amp;md5=e061d12f8d05f0b3534174d87aae1e16&quot; shape=&quot;rect&quot;&gt;www.virtualshareholdermeeting.com/AGEN2026&lt;/a&gt; and enter the 16-digit control number found in their proxy materials. Guests may also access the Annual Shareholders Meeting, but in listen-only mode. No control number is required for guests.

&lt;/p&gt;&lt;p&gt;
&lt;b&gt;Webcast Information:&lt;/b&gt;

&lt;/p&gt;&lt;p&gt;
&lt;b&gt;Date&lt;/b&gt;:</description>
   <guid isPermaLink="true">http://www.streetinsider.com/Business+Wire/Agenus+Announces+Virtual+2026+Annual+Shareholders+Meeting/26592179.html</guid>
   <pubDate>Tue, 02 Jun 2026 16:30:00 -0400</pubDate>
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   <description>&lt;p&gt;Agenus Inc. (NASDAQ: AGEN) announced retrospective data showing that artificial intelligence analysis of routine tumor images identified patients more likely to respond to its experimental cancer treatment combination.&lt;/p&gt;&lt;p&gt;The analysis used Noetik's TARIO-2 platform to examine standard pathology images from 113 patients treated with botensilimab plus balstilimab in a Phase 1b trial. The AI system analyzed spatial tumor microenvironment patterns from hematoxylin and eosin stained tissue samples taken before treatment.&lt;/p&gt;&lt;p&gt;In patients with microsatellite stable metastatic colorectal cancer without active liver metastases, the AI-identified subgroup showed a 64% response rate compared to 9% in the remaining patients. The AI-identified group also demonstrated</description>
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   <title>Agenus reports AI analysis shows improved response rates for cancer treatment</title>
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   <description>&lt;p&gt;Agenus Inc. (NASDAQ: AGEN) announced retrospective data showing that artificial intelligence analysis of routine tumor images identified patients more likely to respond to its experimental cancer treatment combination.&lt;/p&gt;&lt;p&gt;The analysis used Noetik's TARIO-2 platform to examine standard pathology images from 113 patients treated with botensilimab plus balstilimab in a Phase 1b trial. The AI system analyzed spatial tumor microenvironment patterns from hematoxylin and eosin stained tissue samples taken before treatment.&lt;/p&gt;&lt;p&gt;In patients with microsatellite stable metastatic colorectal cancer without active liver metastases, the AI-identified subgroup showed a 64% response rate compared to 9% in the remaining patients. The AI-identified group also demonstrated</description>
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   <title>Agenus reports AI analysis shows improved response rates for cancer treatment</title>
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   <description>&lt;p&gt;Agenus Inc. (NASDAQ: AGEN) announced retrospective data showing that artificial intelligence analysis of routine tumor images identified patients more likely to respond to its experimental cancer treatment combination.&lt;/p&gt;&lt;p&gt;The analysis used Noetik's TARIO-2 platform to examine standard pathology images from 113 patients treated with botensilimab plus balstilimab in a Phase 1b trial. The AI system analyzed spatial tumor microenvironment patterns from hematoxylin and eosin stained tissue samples taken before treatment.&lt;/p&gt;&lt;p&gt;In patients with microsatellite stable metastatic colorectal cancer without active liver metastases, the AI-identified subgroup showed a 64% response rate compared to 9% in the remaining patients. The AI-identified group also demonstrated</description>
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   <title>Agenus reports AI analysis shows improved response rates for cancer treatment</title>
   <link>http://www.streetinsider.com/FDA/Agenus+reports+AI+analysis+shows+improved+response+rates+for+cancer+treatment/26536499.html</link>
   <description>&lt;p&gt;Agenus Inc. (NASDAQ: AGEN) announced retrospective data showing that artificial intelligence analysis of routine tumor images identified patients more likely to respond to its experimental cancer treatment combination.&lt;/p&gt;&lt;p&gt;The analysis used Noetik's TARIO-2 platform to examine standard pathology images from 113 patients treated with botensilimab plus balstilimab in a Phase 1b trial. The AI system analyzed spatial tumor microenvironment patterns from hematoxylin and eosin stained tissue samples taken before treatment.&lt;/p&gt;&lt;p&gt;In patients with microsatellite stable metastatic colorectal cancer without active liver metastases, the AI-identified subgroup showed a 64% response rate compared to 9% in the remaining patients. The AI-identified group also demonstrated</description>
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   <title>Agenus reports melanoma trial data for drug combination BOT+BAL</title>
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&lt;p&gt;Agenus Inc. (NASDAQ: AGEN) presented Phase 2 trial data for its drug combination botensilimab and balstilimab in patients with advanced melanoma that had resisted prior checkpoint therapy at the American Society of Clinical Oncology Annual Meeting.&lt;/p&gt;

&lt;p&gt;The study included 36 heavily pretreated patients with advanced cutaneous melanoma whose disease had resisted prior anti-PD-(L)1 therapy. The trial showed a median overall survival of 16.6 months, with 42% of patients alive at two years. The confirmed objective response rate was 22%.&lt;/p&gt;

&lt;p&gt;Among patients who responded to treatment, 86% remained in response at 12 months, with median duration of response not reached. In a subgroup</description>
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   <title>Agenus reports melanoma trial data for drug combination BOT+BAL</title>
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&lt;p&gt;Agenus Inc. (NASDAQ: AGEN) presented Phase 2 trial data for its drug combination botensilimab and balstilimab in patients with advanced melanoma that had resisted prior checkpoint therapy at the American Society of Clinical Oncology Annual Meeting.&lt;/p&gt;

&lt;p&gt;The study included 36 heavily pretreated patients with advanced cutaneous melanoma whose disease had resisted prior anti-PD-(L)1 therapy. The trial showed a median overall survival of 16.6 months, with 42% of patients alive at two years. The confirmed objective response rate was 22%.&lt;/p&gt;

&lt;p&gt;Among patients who responded to treatment, 86% remained in response at 12 months, with median duration of response not reached. In a subgroup</description>
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   <title>Agenus reports melanoma trial data for drug combination BOT+BAL</title>
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   <description>

&lt;p&gt;Agenus Inc. (NASDAQ: AGEN) presented Phase 2 trial data for its drug combination botensilimab and balstilimab in patients with advanced melanoma that had resisted prior checkpoint therapy at the American Society of Clinical Oncology Annual Meeting.&lt;/p&gt;

&lt;p&gt;The study included 36 heavily pretreated patients with advanced cutaneous melanoma whose disease had resisted prior anti-PD-(L)1 therapy. The trial showed a median overall survival of 16.6 months, with 42% of patients alive at two years. The confirmed objective response rate was 22%.&lt;/p&gt;

&lt;p&gt;Among patients who responded to treatment, 86% remained in response at 12 months, with median duration of response not reached. In a subgroup</description>
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   <title>Agenus reports melanoma trial data for drug combination BOT+BAL</title>
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   <description>

&lt;p&gt;Agenus Inc. (NASDAQ: AGEN) presented Phase 2 trial data for its drug combination botensilimab and balstilimab in patients with advanced melanoma that had resisted prior checkpoint therapy at the American Society of Clinical Oncology Annual Meeting.&lt;/p&gt;

&lt;p&gt;The study included 36 heavily pretreated patients with advanced cutaneous melanoma whose disease had resisted prior anti-PD-(L)1 therapy. The trial showed a median overall survival of 16.6 months, with 42% of patients alive at two years. The confirmed objective response rate was 22%.&lt;/p&gt;

&lt;p&gt;Among patients who responded to treatment, 86% remained in response at 12 months, with median duration of response not reached. In a subgroup</description>
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   <title>Agenus reports melanoma trial data for drug combination BOT+BAL</title>
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   <description>

&lt;p&gt;Agenus Inc. (NASDAQ: AGEN) presented Phase 2 trial data for its drug combination botensilimab and balstilimab in patients with advanced melanoma that had resisted prior checkpoint therapy at the American Society of Clinical Oncology Annual Meeting.&lt;/p&gt;

&lt;p&gt;The study included 36 heavily pretreated patients with advanced cutaneous melanoma whose disease had resisted prior anti-PD-(L)1 therapy. The trial showed a median overall survival of 16.6 months, with 42% of patients alive at two years. The confirmed objective response rate was 22%.&lt;/p&gt;

&lt;p&gt;Among patients who responded to treatment, 86% remained in response at 12 months, with median duration of response not reached. In a subgroup</description>
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   <title>Agenus reports melanoma trial data for drug combination BOT+BAL</title>
   <link>http://www.streetinsider.com/FDA/Agenus+reports+melanoma+trial+data+for+drug+combination+BOT%2BBAL/26536490.html</link>
   <description>

&lt;p&gt;Agenus Inc. (NASDAQ: AGEN) presented Phase 2 trial data for its drug combination botensilimab and balstilimab in patients with advanced melanoma that had resisted prior checkpoint therapy at the American Society of Clinical Oncology Annual Meeting.&lt;/p&gt;

&lt;p&gt;The study included 36 heavily pretreated patients with advanced cutaneous melanoma whose disease had resisted prior anti-PD-(L)1 therapy. The trial showed a median overall survival of 16.6 months, with 42% of patients alive at two years. The confirmed objective response rate was 22%.&lt;/p&gt;

&lt;p&gt;Among patients who responded to treatment, 86% remained in response at 12 months, with median duration of response not reached. In a subgroup</description>
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   <title>Agenus reports melanoma trial data for drug combination BOT+BAL</title>
   <link>http://www.streetinsider.com/FDA/Agenus+reports+melanoma+trial+data+for+drug+combination+BOT%2BBAL/26536490.html</link>
   <description>

&lt;p&gt;Agenus Inc. (NASDAQ: AGEN) presented Phase 2 trial data for its drug combination botensilimab and balstilimab in patients with advanced melanoma that had resisted prior checkpoint therapy at the American Society of Clinical Oncology Annual Meeting.&lt;/p&gt;

&lt;p&gt;The study included 36 heavily pretreated patients with advanced cutaneous melanoma whose disease had resisted prior anti-PD-(L)1 therapy. The trial showed a median overall survival of 16.6 months, with 42% of patients alive at two years. The confirmed objective response rate was 22%.&lt;/p&gt;

&lt;p&gt;Among patients who responded to treatment, 86% remained in response at 12 months, with median duration of response not reached. In a subgroup</description>
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   <title>Agenus reports melanoma trial data for drug combination BOT+BAL</title>
   <link>http://www.streetinsider.com/FDA/Agenus+reports+melanoma+trial+data+for+drug+combination+BOT%2BBAL/26536490.html</link>
   <description>

&lt;p&gt;Agenus Inc. (NASDAQ: AGEN) presented Phase 2 trial data for its drug combination botensilimab and balstilimab in patients with advanced melanoma that had resisted prior checkpoint therapy at the American Society of Clinical Oncology Annual Meeting.&lt;/p&gt;

&lt;p&gt;The study included 36 heavily pretreated patients with advanced cutaneous melanoma whose disease had resisted prior anti-PD-(L)1 therapy. The trial showed a median overall survival of 16.6 months, with 42% of patients alive at two years. The confirmed objective response rate was 22%.&lt;/p&gt;

&lt;p&gt;Among patients who responded to treatment, 86% remained in response at 12 months, with median duration of response not reached. In a subgroup</description>
   <guid isPermaLink="true">http://www.streetinsider.com/FDA/Agenus+reports+melanoma+trial+data+for+drug+combination+BOT%2BBAL/26536490.html</guid>
   <pubDate>Thu, 21 May 2026 17:00:39 -0400</pubDate>
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   <title>Agenus and Noetik Present ASCO 2026 Data Linking AI Analysis of Routine Pretreatment Tumor Pathology Images to Response and Survival with BOT+BAL in MSS Metastatic CRC</title>
   <link>http://www.streetinsider.com/Press+Releases/Agenus+and+Noetik+Present+ASCO+2026+Data+Linking+AI+Analysis+of+Routine+Pretreatment+Tumor+Pathology+Images+to+Response+and+Survival+with+BOT%2BBAL+in+MSS+Metastatic+CRC/26536446.html</link>
   <description>
&lt;ul class=&quot;bwlistdisc&quot;&gt;
&lt;li&gt;
Noetik’s TARIO-2 platform analyzed routine pretreatment H&amp;amp;E images from 113 BOT+BAL-treated patients and identified spatial tumor microenvironment patterns associated with response and survival

&lt;/li&gt;
&lt;li&gt;
In a retrospective analysis of refractory MSS metastatic colorectal cancer without active liver metastases, the AI-identified subgroup had a 64% response rate to BOT+BAL, compared with 9% in the remaining cohort

&lt;/li&gt;
&lt;li&gt;
Overall survival was significantly improved in the AI-identified MSS mCRC subgroup, with median overall survival not reached and a hazard ratio of 0.18 versus the remaining cohort

&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;    LEXINGTON, Mass.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=http%3A%2F%2Fwww.agenusbio.com&amp;amp;esheet=54540504&amp;amp;newsitemid=20260521604737&amp;amp;lan=en-US&amp;amp;anchor=Agenus&amp;amp;index=1&amp;amp;md5=7176bf284d7f3490810073a6a65dc54d&quot; shape=&quot;rect&quot;&gt;&lt;b&gt;Agenus&lt;/b&gt;&lt;/a&gt;&lt;b&gt; Inc. (Nasdaq: AGEN)&lt;/b&gt;, a leader in immuno-oncology innovation, today announced</description>
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   <pubDate>Thu, 21 May 2026 17:00:00 -0400</pubDate>
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