Nuvalent Appoints Ron Squarer to Board of Directors

CAMBRIDGE, Mass., Dec. 10, 2025 /PRNewswire/ -- Nuvalent, Inc. (Nasdaq: NUVL), a clinical-stage biopharmaceutical company focused on creating precisely targeted therapies for clinically proven kinase targets in cancer, today announced the appointment of Ron Squarer to its Board of Directors.

"We welcome Ron to our Board of Directors, where his personal dedication to advancing oncology therapeutics, demonstrated success in evolving research and development organizations to fully integrated businesses, and proven global commercial acumen will strengthen and sharpen our pre-launch preparation," said James Porter, Ph.D., Chief Executive Officer at Nuvalent. "We look forward to leveraging his deep expertise as we advance toward the potential first approval and launch of zidesamtinib for TKI pre-treated ROS1-positive non-small cell lung cancer in 2026."

Mr. Squarer brings more than 30 years of proven leadership in oncology drug development and commercialization to the Nuvalent Board. Most recently, he served as the Board Chair of Deciphera Pharmaceuticals, which was acquired by Ono Pharmaceuticals in 2024. He also served as the Chief Executive Officer of Array Biopharma, where he oversaw the research, development, and successful commercialization of several oncology treatments, as well as the 2019 acquisition of the company by Pfizer. Prior to Array, Mr. Squarer held positions of increasing responsibility with Hospira, a global pharmaceutical and medical device company. Earlier in his career, he served as Senior Vice President of Global Corporate and Business Development at Mayne Pharma and held leadership roles at Pfizer and SmithKline Beecham Pharmaceuticals in the U.S. and Europe.

"Nuvalent's demonstrated ability to combine elegant molecular design with disciplined development and a clear understanding of medical needs has resulted in a pipeline of novel kinase inhibitors with the potential to make a meaningful impact for patients," said Mr. Squarer. "This is the type of innovation that continues to advance toward a future where oncogene-driven cancers may one day be managed as a chronic condition more often than as a life-threatening disease. It is a privilege to join the Board of Directors as the team prepares for the potential commercialization of its first medicine, and I look forward to partnering towards our shared goal of delivering a new generation of precisely targeted therapies to patients with cancer."

Mr. Squarer currently serves as the Board Chair of ADC Therapeutics and as a Board member at Travere Therapeutics. Mr. Squarer earned an M.B.A. from the Kellogg School of Management, Northwestern University, and a bachelor's degree in biochemistry from the University of California, Berkeley.

About Nuvalent
Nuvalent, Inc. (Nasdaq: NUVL) is a clinical-stage biopharmaceutical company focused on creating precisely targeted therapies for patients with cancer, designed to overcome the limitations of existing therapies for clinically proven kinase targets. Leveraging deep expertise in chemistry and structure-based drug design, we develop innovative small molecules that have the potential to overcome resistance, minimize adverse events, address brain metastases, and drive more durable responses. Nuvalent is advancing a robust pipeline with investigational candidates for ROS1-positive, ALK-positive, and HER2-altered non-small cell lung cancer, and multiple discovery-stage research programs.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, implied and express statements regarding Nuvalent's strategy, business plans, and focus; the expected timing of potential product approvals; the potential of Nuvalent's pipeline programs; Nuvalent's potential commercialization of its product candidates, if approved; Nuvalent's research and development programs for the treatment of cancer; and risks and uncertainties associated with drug development. The words "may," "might," "will," "could," "would," "should," "expect," "plan," "anticipate," "aim," "goal," "intend," "believe," "expect," "estimate," "seek," "predict," "future," "project," "potential," "continue," "target" or the negative of these terms and similar words or expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Drug development and commercialization involve a high degree of risk, and only a small number of research and development programs result in commercialization of a product. You should not place undue reliance on these statements or the scientific data presented.

Any forward-looking statements in this press release are based on management's current expectations and beliefs and are subject to a number of risks, uncertainties, and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation: risks that Nuvalent may not fully enroll its clinical trials or that enrollment will take longer than expected; unexpected concerns that may arise from additional data, analysis, or results obtained during preclinical studies and clinical trials; the risk that preliminary results of clinical trials may not be predictive of future results from the same or other trials; the risk that results of earlier clinical trials may not be predictive of the results of later-stage clinical trials; the risk that data from our clinical trials may not be sufficient to support registration and that Nuvalent may be required to conduct one or more additional studies or trials prior to seeking registration of our product candidates; the occurrence of adverse safety events; risks that the FDA may not approve our potential products on the timelines we expect, or at all; risks of unexpected costs, delays, or other unexpected hurdles; risks that Nuvalent may not be able to nominate drug candidates from its discovery programs; the direct or indirect impact of public health emergencies or global geopolitical circumstances on the timing and anticipated timing and results of Nuvalent's clinical trials, strategy, and future operations; the timing and outcome of Nuvalent's planned interactions with regulatory authorities; and risks related to obtaining, maintaining, and protecting Nuvalent's intellectual property. These and other risks and uncertainties are described in greater detail in the section entitled "Risk Factors" in Nuvalent's Quarterly Report on Form 10-Q for the quarter ended September 30, 2025, as well as any prior and subsequent filings with the Securities and Exchange Commission. In addition, any forward-looking statements represent Nuvalent's views only as of today and should not be relied upon as representing its views as of any subsequent date. Nuvalent explicitly disclaims any obligation to update any forward-looking statements.

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SOURCE Nuvalent, Inc.